Index

Aging isnt one thing. Index, a revolutionary at-home biological age test developed by Elysium Health, now measures 10 different aspects of aging using the latest generation technology in the science of epigenetics. With Index you'll receive

• Biological age the age your body is expected to perform or function.
• Cumulative rate of aging the pace at which your body has been aging.
• System age scores the biological age of nine different systems, including brain, heart, metabolic, and immune, for deeper insights into how youve been aging.
• Science-backed recommendations evidence-based lifestyle recommendations you can use to adopt healthier habits.
• Longevity research participate directly in research with the Aging Research Center by Elysium Health.

With the superior precision of our Algorithmic Platform for Epigenetic Examination (APEX), Elysium calculates your biological age and system ages by examining sites on your DNA where methylation has taken place. DNA methylation is an epigenetic modification that influences how genes are expressed and their genome-wide pattern changes predictably with age.

We employ the custom Elysium chip, developed with the help of biotechnology leader Illumina, to analyze your methylation patterns via a computational approach that significantly improves upon past biological clocks.

• The most precise epigenetic biological age test
  Precision and reliability are significant challenges for measuring biological age at the individual level. To develop the most precise and reliable test, Elysium partnered with Morgan Levine, Ph.D., of Yale Universitya leading epigenetics researcher. Index leverages a unique machine learning solution demonstrated inNature Agingto be the most precise and reliable among published epigenetic age measures.
• A better predictor of physical functioning status
  Index is more predictive of physical functioning status than prior leading measures. This means biological age as measured by Index corresponds closely with how your body is expected to perform and is a more accurate predictor of how quickly youve been aging.
• Deeper insights into how your body has been aging
  Each of the nine system measures is based on DNA methylation signatures present in your genome that reflect a number of biomarkers relevant to that particular system. Biomarkers were chosen for how closely they are associated with aging and their ability to indicate overall long-term health and wellness. Elysium is the first to offer this level of insight.
• Better ability to track lifestyle changes over time
  Motivated to make changes to your lifestyle and track the impact on your rate of aging? You need to eliminate noise over time. Repeatability and better prediction of physical functioning status add up to a better ability to track the impact of your lifestyle changes on your biological age and system age scores.

Approximately six weeks after receiving your saliva sample, well send an email letting you know your results are ready. Before that, a lot happens behind the scenes.

• Week 1 to 2 DNA Extraction
  We extract your DNA and use a process called bisulfite conversion to distinguish methylated from unmethylated DNA across your genome.
• Week 3 Methylation Profiling
  The bisulfite-converted DNA gets loaded onto the Elysium chip and scanned to create your methylation profile. Quality control ensures your data is robust and complete.
• Week 4 to 5 Calculating Biological Age and System Age Scores
  With the superior precision of APEX, we analyze methylated sites across your genome to calculate your biological age and system age scores.
• Week 6+ Tracking Your Progress
  Use your report results and recommendations to see if making healthy changes can impact how you age.